朱小(xiǎo)明 婦産(chǎn)科(kē)
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專長(cháng):生殖衰老與不孕;輔助生殖與優生技(jì )術;生殖遺傳與出生缺陷防控。

詳細介紹

1982年12月南通大學(xué)醫(yī)學(xué)院醫(yī)學(xué)系本科(kē)畢業,獲醫(yī)學(xué)學(xué)士學(xué)位;1988 年8月山(shān)東大學(xué)醫(yī)學(xué)院婦産(chǎn)科(kē)學(xué)碩士研究生畢業,獲醫(yī)學(xué)碩士學(xué)位;2006 年6月浙江大學(xué)醫(yī)學(xué)院婦産(chǎn)科(kē)學(xué)博士研究生畢業,獲醫(yī)學(xué)博士學(xué)位。從1982-至今,一直從事婦産(chǎn)科(kē)學(xué)臨床、教學(xué)、科(kē)研和管理(lǐ)工(gōng)作(zuò)。先後在南通大學(xué)附屬第一醫(yī)院、山(shān)東大學(xué)附屬省立醫(yī)院和浙江大學(xué)附屬婦産(chǎn)科(kē)醫(yī)院就職。2000-2001年以國(guó)家公(gōng)派訪問學(xué)者身份赴加拿(ná)大British Columbia 大學(xué)進修學(xué)習生殖内分(fēn)泌。研究方向: 1、生殖衰老與不孕;2、輔助生殖與優生技(jì )術;3、生殖安(ān)全與出生缺陷防控。先後參編專著一部;教材二部;公(gōng)開發表SCI論文(wén)20篇;主持國(guó)家自然科(kē)學(xué)基金面上項目2項(No. 30471642;No. 81070541);參與國(guó)家“973”、“863”等重大科(kē)研項目和其它國(guó)家及省部級科(kē)研項目多(duō)項。

學(xué)術團體(tǐ)和社會兼職:

1.教育部普通高校五年制醫(yī)學(xué)本科(kē)《婦産(chǎn)科(kē)學(xué)》教材編委

2.教育部主管《現代婦産(chǎn)科(kē)進展》雜志(zhì)編委 



業績一覽: 

一、代表性論著: 

1.Zheng YM, Li L, Zhou LM, Le F, Cai LY, Yu P, Zhu YR, Liu XZ, Wang LY, Li LJ, Lou YY, Xu XR, Lou HY, Zhu XM (朱小(xiǎo)明), Sheng JZ, Huang HF, Jin F*: Alterations in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology. Hum Reprod 2013, 28(9):2570-80

2.Xu XR, Fu R, Wang LY, Wang N, Zhang F, Le F, Li L, Li LJ, Liu XZ, Zheng YM,. Lou HY, Jiang SW, Zhu XM (朱小(xiǎo)明), Huang HF, Jin F*: Epigenetic inheritance of paternally expressed imprinted genes in the testes of ICSI mice. Curr Pharm Des 2013. PMID:2390980 

3.Wang LY, Wang N, Le F, Li L, Li LJ, Liu XZ, Zheng YM, Lou HY, Xu XR, Zhu XM (朱小(xiǎo)明), Zhu YM, Huang HF, Jin F*: Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice. J Zhejiang Univ Sci B 2013, 14:372-381. 

4.Wang LY, Le F, Wang N, Li L, Liu XZ, Zheng YM, Lou HY, Xu XR, Chen YL, Zhu XM (朱小(xiǎo)明), Huang HF, Jin F: Alteration of fatty acid metabolism in the liver, adipose tissue, and testis of male mice conceived through assisted reproductive technologies: fatty acid metabolism in ART mice. Lipids Health Dis 2013, 12:5. 

5.Wu YT, Wang TT, Chen XJ, Zhu XM (朱小(xiǎo)明), Dong MY, Sheng JZ, Xu CM, Huang HF: Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders. Reprod Biol Endocrinol 2012, 10:6. 

6.Yin LJ, Zhang Y, Lv PP, He WH, Wu YT, Liu AX, Ding GL, Qu F, Xu CM, Dong MY, Zhu XM (朱小(xiǎo)明) and Huang HF: Insufficient maintenance DNA methylation is associated with abnormal embryonic development. BMC Med. 2012 Mar 13;10:26

7.Feng C, Tian S, Zhang Y, He J, Zhu XM (朱小(xiǎo)明), Zhang D, Sheng JZ, Huang HF, General imprinting status is stable in assisted reproduction-conceived offspring. Fertil Steril, 2011; 96:1417–23. 

8.He RH, Zhu XM (朱小(xiǎo)明,通訊作(zuò)者), How to deal with fluid in the endometrial cavity during assisted reproductive techniques. Curr Opin Obstet Gynecol. 2011; 23(3):190-4.

9.He RH, Gao HJ, Li YQ, and Zhu XM (朱小(xiǎo)明,通訊作(zuò)者), The associated factors to endometrial cavity fluid and the relevant impact on the IVF-ET outcome. Reprod Biol Endocrinol, 2010. 8:46. 

10.Tang L, Zhang Y, Pan H, Luo Q, Zhu X-M (朱小(xiǎo)明), Dong M-Y, Leung P, Sheng J-Z, and Huang H-F, Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell. Reprod Biol Endocrinol, 2009. 7(1):144. 

11.Lin K, Zhu X (朱小(xiǎo)明), Xu H, Liang Z, Zhang X: Reproductive outcome following resectoscope metroplasty in women having a complete uterine septum with double cervix and vagina. Int J Gynaecol Obstet. 2009;105:25-8

12.Zhu XM (朱小(xiǎo)明), Zhu YM, Xu CM, Qian YL, Jin F, and Huang HF, Autologous mature follicular fluid: its role in in vitro maturation of human cumulus-removed oocytes. Fertil Steril, 2008. 90(4):1094-102. 

13.Wu YT, Tang L, Cai J, Lu XE, Xu J, Zhu XM (朱小(xiǎo)明), Luo Q, Huang HF*: High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development. Hum Reprod 2007, 22:1526-1531.

14.Liu AX, Zhu YM, Luo Q, Wu YT, Gao HJ, Zhu XM (朱小(xiǎo)明), Xu CM, Huang HF: Specific peptide patterns of follicular fluids at different growth stages analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Biochimica Et Biophysica Acta-General Subjects 2007, 1770:29-38.

15.Luo Q, Ning WX, Wu YT, Zhu XM (朱小(xiǎo)明), Jin F, Sheng JZ, Huang HF, Altered expression of interleukin-18 in ectopic and eutopic endometrium of women with endometriosis. J Reprod Immunol 2006; 72:108-17

16.Luo Q, Yang J, Zeng QL, Zhu XM (朱小(xiǎo)明), Qian YL, Huang HF: 50-Hertz electromagnetic fields induce gammaH2AX foci formation in mouse preimplantation embryos in vitro. Biol Reprod. 2006; 75:673-80

17.Jin L, Zhu XM (朱小(xiǎo)明,共同第一作(zuò)者), Luo Q, Qian Y, Jin F, and Huang HF, A novel SNP at exon 17 of INSR is associated with decreased insulin sensitivity in Chinese women with PCOS. Mol Hum Reprod, 2006. 12:151-5

18.Ruan HC, Zhu XM (朱小(xiǎo)明,共同第一作(zuò)者), Luo Q, Liu AX, Qian YL, Zhou CY, Jin F, Huang HF, and Sheng JZ, Ovarian stimulation with GnRH agonist, but not GnRH antagonist, partially restores the expression of endometrial integrin beta3 and leukaemia-inhibitory factor and improves uterine receptivity in mice. Hum Reprod, 2006. 21:2521-9. 

19.朱小(xiǎo)明,金帆和黃荷鳳:人自體(tǐ)胚胎幹細胞創建技(jì )術的研究進展[J]. 《國(guó)外醫(yī)學(xué)》(計劃生育分(fēn)冊)2006; 25:121-124

20.朱小(xiǎo)明,蔡婕和黃荷鳳:卵巢低反應的診斷标準和預測[J]. 《中(zhōng)國(guó)實用(yòng)婦科(kē)與産(chǎn)科(kē)雜志(zhì)》 2006; 22:388-390

21.朱小(xiǎo)明和黃荷鳳:月經的生理(lǐ)和調節[J]. 《中(zhōng)國(guó)實用(yòng)婦科(kē)與産(chǎn)科(kē)雜志(zhì)》 2004; 20:208-209

22.朱小(xiǎo)明,黃荷鳳和朱依敏:醫(yī)源性多(duō)胎妊娠的倫理(lǐ)問題及對策[J]. 《醫(yī)學(xué)與哲學(xué)》 2003; 22(11):36-38

23.Leung PC, Cheng CK, and Zhu XM (朱小(xiǎo)明), Multi-factorial role of GnRH-I and GnRH-II in the human ovary. Mol Cell Endocrinol, 2003, 202:145-53. 

24.Lau HL, Zhu XM (朱小(xiǎo)明), Leung PC, Chan LW, Chen GF, Chan PS, Yu KL, and Chan FL, Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates. Int J Oncol, 2001. 19:1193-201. 

25.朱小(xiǎo)明,等:甲氨蝶呤和丙酸睾丸酮輔助加強藥物(wù)流産(chǎn)的臨床觀察。《現代婦産(chǎn)科(kē)進展》2001;10:55~57

26.朱小(xiǎo)明,等:婦産(chǎn)科(kē)學(xué)臨床實習教學(xué)和管理(lǐ)的研究報告。《中(zhōng)國(guó)高等醫(yī)學(xué)教育》1999;(5):59~61

27.朱小(xiǎo)明:人工(gōng)破膜後暫緩靜點催産(chǎn)素的引産(chǎn)方法探讨。《中(zhōng)國(guó)實用(yòng)婦科(kē)與産(chǎn)科(kē)雜志(zhì)》1992;8:203~205

二、承擔課題: 

1.國(guó)家重大科(kē)學(xué)研究計劃(2012CB944900):輔助生殖誘發胚胎源性疾病的風險評估和機制研究,科(kē)技(jì )部,起止時間:2012-2016,研究骨幹

2.國(guó)家自然科(kē)學(xué)基金面上項目(81070541):輔助生殖子代低出生體(tǐ)重的基因組印記狀态及發病機制研究,2011-2013,課題負責人

3.國(guó)家自然科(kē)學(xué)基金面上項目(30671161):輔助生殖技(jì )術出生的子代基因組印記表達譜的變化及其機制研究,2007-2009,課題負責人

4.國(guó)家自然科(kē)學(xué)基金—中(zhōng)加健康研究合作(zuò)計劃項目(30711120577):卵細胞源性生長(cháng)因子對人類卵泡發育調節機制的研究,2008.1-2010.12,研究骨幹

5.國(guó)家科(kē)技(jì )部863課題(20060102A1022):我國(guó)人類(疾病)胚胎幹細胞庫的建立與應用(yòng),2007-2011,研究骨幹

6.國(guó)家自然科(kē)學(xué)基金面上項目(30471642):親緣性基因印記校正的雌核發育/雄核發育技(jì )術創建人自體(tǐ)胚胎幹細胞的研究,2005-2007,研究骨幹

三、出版物(wù)編寫

1.《其它内分(fēn)泌疾病與閉經》。見陳子江和林金芳主編:(中(zhōng)華醫(yī)學(xué)會繼續醫(yī)學(xué)教育教材)《閉經診斷治療指南及解讀》. 北京. 清華同方光盤電(diàn)子出版社. 2012-07-01:P47~52 (ISBN 978-7-89477-323-4)

2.《第七章 人類生殖工(gōng)程技(jì )術應用(yòng)中(zhōng)的倫理(lǐ)學(xué)問題及相關法律法規》。見喬傑主編:(全國(guó)高等學(xué)校教材)《生殖工(gōng)程學(xué)》. 北京. 人民(mín)衛生出版社. 2007:P213~223 (ISBN 978 - 7 -117 – 08886 – 2/R.8887)

3.《第四章 妊娠生理(lǐ)》和《第五章 妊娠診斷》。見孔北華主編:(全國(guó)高等學(xué)校醫(yī)學(xué)規劃教材)《婦産(chǎn)科(kē)學(xué)》. 北京. 高等教育出版社. 2005:P33~53 (ISBN 7 - 04 -016773 – 5)

主攻學(xué)科(kē):生殖内分(fēn)泌、輔助生殖和計劃生育


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